Uses
For research studies which involve aspiration
of luminal contents, and/or delivery of tracer or test substances
to the gut lumen.
General principles
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Aqueous solutions can be delivered
down lumina as small as 0.28mm, dependent on assembly
length and the required rate of delivery.
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Viscous liquids require substantially
larger size channels than solutions with a viscocity similar
to water.
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The diameter of the channel required
for aspiration depends also on the viscosity and volume
of the material aspirated, and the size of any suspended
particles.
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Effective aspiration requires the use
of methods to release any vacuum generated in the aspiration
line by the mucosa causing plugging of aspiration ports.
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Channels other than the aspiration
channel can be used to release vacuum, by creating vents
from these channels into the aspiration channel at strategic
points.
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Luminal aspiration/infusion assemblies
can be equipped with tip weights, balloons and stiffeners
to aid intubation, with methods described in Technical
Note 5, Version 2, pages 70 to 74.
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It is feasible to make aspiration/infusion
assemblies from any of the Dentsleeve
assemblies, and for these to combine manometry with these
other functions.
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The E63 extrusion has been designed
specially for infusion studies which do not require large
occlusive balloons. |
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E63 Infusion Assemblies
This extrusion, which
is shown below, is designed primarily for infusion studies,
being especially suitable for bio-availability studies on test
pharmaceuticals.
The overall diameter of 3mm gives excellent tolerance of prolonged
deep intubation.
The four channels can be allocated to various purposes that
aid infusion studies such as
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delivery of one or more
test substances at different sites
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aspiration of contents
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balloon inflation
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manometry
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transmucosal potential difference recordings
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Attributes of specific layouts
Assembly design is entirely dependent
on the nature of the study. Accordingly, no suggested 'standard'
designs are shown.
Dentsleeve
is happy to consider the application and to advise on assembly
designs that are best suited to this.
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Accessories
for aspiration assemblies
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Balloons of various types can be supplied
- see Section 4, pages 49 and 50.
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Radio-opaque marking is possible -
see Section 4, page 52.
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Tip weights and balloons can be installed
to aid passage across the pylorus and along the small
and large intestine - see Section 4, pages 49 to 51 and
Technical Note5, Version 2, pages 70 to 74.
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2+1+1 extrusion E63
Lumina 0.6 mm, 0.8 mm
and oval 1.5x1.2 mm
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